Objectives: To Evaluate the efficacy of esterified hyaluronic acid in the closure of central tympanic membrane perforation when added to a temporalis fascia and to compare its success rate in term of healing and hearing, with the of the superficial temporalis fascia grafts when used alone in the closure of central tympanic membrane perforations.

Results: Twenty-two patients classified into group A (hyaluronic acid temporalis fascia graft myringoplasty) and group B (temporalis fascia graft myringoplasty) (11 patients in each group) were included in the study. Healing occurred in 81.82% in group A, vs 72.73% in group B (p=0.61).