Zahra ShojaeiGeneral Practitioner, Iran
Title: Clinicopathological characteristics and survival rate of patients with laryngeal squamous cell carcinoma: A retrospective study during 2011–2017 in Yazd, Iran
The aim of the current study was to determine the clinicopathological characteristics of patients with laryngeal squamous cell carcinoma and evaluation the effect of prognostic factors on survival rate. The archives of all patients with laryngeal squamous cell carcinoma (2011-2017) were studied. Patients’ data were extracted using a checklist that included age, gender, tumor stage, treatment methods used, and survival rate in months. All data were analyzed by SPSS-17 software with the Chi-square test, the Kaplan-Meier, and the log-rank tests at a statistical significance level of P<0.05. Out of 109 patients with laryngeal cancer, 99 were male and 10 were female. Patients in stages 1,2 and also in stage 3 had longer overall survival compared to patients in stage 4. The mean survival rate was found to be significantly lower in patients in stage 4 compared to those in the other stages of the disease. Patients in the age group (35-59) had longer overall survival compared to the older age group (60-89). Patients at stage 3 of the disease who had not undergone chemotherapy had greater longevity compared to the ones who had undergone the therapy. Patients at stage 4 who had not undergone laryngectomy had a much lower survival rate compared to those who had used both surgery and radiotherapy or chemoradiation. Surgery and radiotherapy can positively affect the mean survival rate in patients at stages 1, and 2 of laryngeal carcinoma. Together with surgery and chemotherapy or chemoradiation have a positive effect on the survival of patients in advanced stages of the disease.
Zahra Shojaei received an MD degree from the Shahid Sadoughi University of Medical Science, Yazd, IRAN in 2022. She currently works as a General Practitioner. She has been a research assistant in several projects since 2016 and she has 3 publications in the field of pathology. She found her interest in cancer research.