Peter Catalano
, St Elizabeth's Medical Center, USATitle : Minimally invasive nasal airway surgery can reverse ADHD in children with SDB
Abstract
Introduction: Attention Deficit Disorder (ADD) and Attention
Deficit Hyperactivity Disorder (ADHD) are increasingly diagnosed in children,
and estimated to occur in nearly 10% of children in the US. While their
etiology can be varied and complex, ADD and ADHD are known to occur in up to
50% of children who exhibit Sleep Disordered Breathing (SDB). The mechanism of
hyperactivity in these children is believed to be directly related to 2
phenomena of SDB: (a) the secretion of adrenaline during sleep to assist
children to breathe through their airway obstruction, and (b) the buildup of
“toxins” in the brain during the day that are not appropriately cleared during
interrupted sleep. Sleep patterns in children with SBD are characterized by
intermittent airway obstruction resulting in episodic hypoxia, sleep
fragmentation due to repeated arousal, mouth breathing, and sleep
deprivation. In the past decade, medical
and behavioral treatment of ADHD has been extensively studied, however no one
has yet evaluated the effect on ADD/ADHD behavior after correcting SDB in these
children. In our study, we compare the changes ADHD behavior before and after
targeted upper airway surgical treatment for SDB in children.
Methods: A prospective pilot study designed to evaluate
the effect of targeted nasal surgery on improving ADHD symptoms in children
with SDB. 72 children with ADHD symptoms who demonstrated SDB as determined by
history, physical exam, and sinus CT-scan were included. The validated nose
score and Barkley deficits in executive functioning scale was obtained at
baseline and 6 months after surgery and compared. Data from this ADHD
evaluation tool was analyzed and compared for each patient using the Reliable Change
Index scale (RCI). Parents completed the assessment tools during the child’s
clinic visits.
Results: 72 patients aged 6-17 years (M 91%; F 9%)
completed the study. For ages 6-11 years, 44% of children showed “highly
significant” improvement in their RCI, and another 20% improved between 75-99%
of the “highly significant” threshold. For children ages 12-17 years, these
numbers were 17% and 67%, respectively.
5% of children in both age groups showed slightly worse RCI scores after
surgery. Combined, 37.7% of children exceeded the RCI threshold for “highly
significant change”, and another 26% improved to between 75-99% of the” highly
significant” threshold. Nose scores were also significantly improved after
surgery (p< .05). There were no surgical complications in this study cohort.
Conclusions: Targeted minimally invasive upper airway surgery
in children with SDB and ADHD symptoms can significantly improve their
executive functioning. This pilot study
shows the importance of restoring upper airway breathing and normal sleep as
part of ADHD management in a majority of children with SDB and ADHD.
Biography
Peter Catalano graduated with a BS from
Columbia University School of Engineering, followed by an MD degree from The
Mount Sinai School of Medicine (MSH) in New York City. Completed Residency at
MSH and became a full-time faculty member (1990-1999) where he became an associate
professor of otolaryngology, neurosurgery, and maxillofacial surgery. He then
became chair of otolaryngology at the Lahey Clinic (2000-2009), followed by
chair of surgery and VP of surgical services at Caritas/Steward Health Care
(2009-2012). Now chief of otolaryngology at SEMC, professor of otolaryngology
at Tufts University, director of rhinology fellowship (SEMC), and medical
director of research for steward. Academically active with over 300 invited
lectures, 25 book chapters, 90+ peer-reviewed publications, member of the
editorial board of 7 medical journals, and editor of 1 journal. President and founder
of the foundation for innovation, education and research in otolaryngology
(2011-present), and organizer of two annual medical conferences, open forum US
and ENT summit. He has worked with numerous medical device companies to help
develop and commercialize numerous minimally invasive surgical tools and
techniques over the past 30 years of clinical practice.