Peter Catalano

, St Elizabeth's Medical Center, USA
Title : Minimally invasive nasal airway surgery can reverse ADHD in children with SDB

Abstract

Introduction: Attention Deficit Disorder (ADD) and Attention Deficit Hyperactivity Disorder (ADHD) are increasingly diagnosed in children, and estimated to occur in nearly 10% of children in the US. While their etiology can be varied and complex, ADD and ADHD are known to occur in up to 50% of children who exhibit Sleep Disordered Breathing (SDB). The mechanism of hyperactivity in these children is believed to be directly related to 2 phenomena of SDB: (a) the secretion of adrenaline during sleep to assist children to breathe through their airway obstruction, and (b) the buildup of “toxins” in the brain during the day that are not appropriately cleared during interrupted sleep. Sleep patterns in children with SBD are characterized by intermittent airway obstruction resulting in episodic hypoxia, sleep fragmentation due to repeated arousal, mouth breathing, and sleep deprivation.  In the past decade, medical and behavioral treatment of ADHD has been extensively studied, however no one has yet evaluated the effect on ADD/ADHD behavior after correcting SDB in these children. In our study, we compare the changes ADHD behavior before and after targeted upper airway surgical treatment for SDB in children.
Methods: A prospective pilot study designed to evaluate the effect of targeted nasal surgery on improving ADHD symptoms in children with SDB. 72 children with ADHD symptoms who demonstrated SDB as determined by history, physical exam, and sinus CT-scan were included. The validated nose score and Barkley deficits in executive functioning scale was obtained at baseline and 6 months after surgery and compared. Data from this ADHD evaluation tool was analyzed and compared for each patient using the Reliable Change Index scale (RCI). Parents completed the assessment tools during the child’s clinic visits.
Results: 72 patients aged 6-17 years (M 91%; F 9%) completed the study. For ages 6-11 years, 44% of children showed “highly significant” improvement in their RCI, and another 20% improved between 75-99% of the “highly significant” threshold. For children ages 12-17 years, these numbers were 17% and 67%, respectively.  5% of children in both age groups showed slightly worse RCI scores after surgery. Combined, 37.7% of children exceeded the RCI threshold for “highly significant change”, and another 26% improved to between 75-99% of the” highly significant” threshold. Nose scores were also significantly improved after surgery (p< .05). There were no surgical complications in this study cohort.
Conclusions: Targeted minimally invasive upper airway surgery in children with SDB and ADHD symptoms can significantly improve their executive functioning.  This pilot study shows the importance of restoring upper airway breathing and normal sleep as part of ADHD management in a majority of children with SDB and ADHD.

Biography

Peter Catalano graduated with a BS from Columbia University School of Engineering, followed by an MD degree from The Mount Sinai School of Medicine (MSH) in New York City. Completed Residency at MSH and became a full-time faculty member (1990-1999) where he became an associate professor of otolaryngology, neurosurgery, and maxillofacial surgery. He then became chair of otolaryngology at the Lahey Clinic (2000-2009), followed by chair of surgery and VP of surgical services at Caritas/Steward Health Care (2009-2012). Now chief of otolaryngology at SEMC, professor of otolaryngology at Tufts University, director of rhinology fellowship (SEMC), and medical director of research for steward. Academically active with over 300 invited lectures, 25 book chapters, 90+ peer-reviewed publications, member of the editorial board of 7 medical journals, and editor of 1 journal. President and founder of the foundation for innovation, education and research in otolaryngology (2011-present), and organizer of two annual medical conferences, open forum US and ENT summit. He has worked with numerous medical device companies to help develop and commercialize numerous minimally invasive surgical tools and techniques over the past 30 years of clinical practice.