Akheel Mohammad
City University Ajman, UAETitle: Evaluation of clinico-pathological parameters and epidermal growth factor receptor status to create a mathematical model for prognosis of oral squamous cell carcinomas
Abstract
Oral Squamous Cell Carcinomas
(OSCC) are the most common type of variant causing oral cancers, contributing
for around 90%. The overall survival of these patients is below 50%. The
postoperative Overall Survival (OS) has not improved over years much despite of
advanced surgical techniques and invention of various anticancer drugs. There
was always a requirement for a non-invasive molecular marker to predict the
prognosis of these patients. The Epidermal Growth Factor (EGF) and their
receptors are not only thought to play a critical but also an influential role
in growth of the cell and differentiation in normal/ healthy tissues. This
study put forward a proposed mathematical model by incorporating all important
histopathological parameters to predict the prognosis of the patients. EGFR
expression is one such important parameter to be considered to develop anti –
EGFR agents to improve the OS of the patients.
Biography
TBA